PKD1 negatively regulates cell invasion, migration and proliferation ability of human osteosarcoma
نویسندگان
چکیده
منابع مشابه
PKD1 negatively regulates cell invasion, migration and proliferation ability of human osteosarcoma.
Osteosarcoma (OS) is a primary malignancy of the bone, with a tendency to metastasize early. Despite intensive chemotherapy and surgical resection, more than 30% of patients develop distant metastases, and the prognosis of patients with metastases is essentially poor. Members of the protein kinase D (PKD) family are serine/threonine kinases, and have been studied in various cancers. Among the t...
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INTRODUCTION Osteosarcoma (OS) is one of high grade malignant bone tumors and is the most commonly encountered malignant bone tumor in children and adolescents. Significant numbers of patients of the disease eventually develop pulmonary metastases and succumb to the disease even after conventional multi-agent chemotherapy and surgical excision. Protein kinase D1 (PKD1), founding member of a new...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2012
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2012.1400